Aras Part Medical International Press International Journal of Medical Parasitology and Epidemiology Sciences 2766-6492 7 Suppl 1 2026 09 18 Structural Characterization of Polypropylene Nanoparticles and the Protective Role of Phycocyanin Against Neurotoxicity and Oxidative Stress in Brain Tissue of Juvenile Rats S28 S35 10.34172/ijmpes.6292 EN Noor Abdultateef Abbas https://orcid.org/0009-0005-3595-5039 Ahmed Jassim Hassan https://orcid.org/0000-0002-3746-6328 Journal Article 10.34172/ijmpes.6292 2026 04 21 2026 06 28 Introduction: Recently, the most common environmental issue is form from nanoplastics. The aim of this research is the determination of the important physiological changes and sever neurotoxicity that cause by exposure to polypropylene nanoparticles (PP NPs) in the juvenile white rats. Also, protective role of this phycocyanin compound. Methods: The experiment was conducted on the 45 albino rats for the 30 days, which were divided into groups that included exposure to the different doses of the nanoparticles (10 and the 25 mg/kg) and the phycocyanin, either individually or combined. To verify the structural and the morphological characteristics of the prepared nanoparticles, X-ray diffraction (XRD) and the scanning electron microscopy (SEM). To evaluate oxidative stress, the levels of the lipid peroxidation (MDA) and the antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD), and the catalase (CAT) were measured in the blood serum. Results: The important oxidative stress that cause by PP NPs was successfully mitigated by phycocyanin. The highest MDA levels (43.01 µmol/L) were recorded in T1, while T5 reduced it to 26.98 µmol/L. There are many antioxidant improvements, as shown by T3 reaching the highest CAT (51.13 IU/L) and GSH (73.32 µmol/L). In stark contrast, the control model firmly maintained peak SOD activity at 43.66 µmol/L. All this that mean neuroprotection is achieved. Conclusion: phycocyanin provides a strong protective role against sever brain neurotoxicity that cause by polypropylene nanoparticles in the current rat study.