Aras Part Medical International Press International Journal of Medical Parasitology and Epidemiology Sciences 2766-6492 5 3 2024 09 29 Rabies Virus: A Major Neglected Tropical Disease 88 91 10.34172/ijmpes.4169 EN Tesfaye Rebuma https://orcid.org/0000-0003-0690-0440 Sanaz Mehdipour REVIEW 10.34172/ijmpes.4169 2023 11 19 2024 07 22 Rabies is among the most neglected tropical diseases. The Lyssavirus genus causes rabies, a deadly zoonotic illness that affects mammals worldwide, including humans. Although pre-exposure and post-exposure prophylaxis (PEP) vaccines are now available, rabies still poses a serious threat to public health, especially in underdeveloped nations. This article looks at the dynamics of rabies transmission, clinical signs, difficulties in diagnosing the disease, and prevention measures. It highlights the vital importance of all-encompassing immunization programs, creative oral vaccination campaigns for wildlife, and joint ventures between the veterinary and medical fields. The World Health Organization’s (WHO’s) global aims for rabies elimination depend on improved surveillance and public education.